Ofer Spiegelstein: search on Z-Library

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1

Is it possible to achieve bio-equivalence between an oral solid immediate-release and an analogue enteric-coated formulation?

Licht, Dannit, Cohen, Rachel, Spiegelstein, Ofer, Rabinovich-Guilatt, Laura, Zholkovsky, Marina, Gilbert, Adrian, Dressman, Jennifer B., Safadi, Muhammad

Journal:

Journal of Pharmacy and Pharmacology

Year:

2016

Language:

english

File:

PDF, 425 KB

english, 2016

2

Identification and Characterization of the Human and Mouse SLC19A3 Gene: A Novel Member of the Reduced Folate Family of Micronutrient Transporter Genes

James D. Eudy, Ofer Spiegelstein, Robert C. Barber, Bogdan J. Wlodarczyk, Jeffrey Talbot, Richard H. Finnell

Journal:

Molecular Genetics and Metabolism

Year:

2000

Language:

english

File:

PDF, 277 KB

english, 2000

3

Pharmacokinetics and Safety of Single and Multiple Doses of Rasagiline in Healthy Japanese and Caucasian Subjects

Elgart, Anna, Rabinovich, Laura, Eyal, Eli, Gross, Aviva, Spiegelstein, Ofer

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2018

Language:

english

File:

PDF, 413 KB

english, 2018

4

Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation

Ofer Spiegelstein, Laura E. Mitchell, Michelle Y. Merriweather, Ned J. Wicker, Qiang Zhang, Edward J. Lammer, Richard H. Finnell

Journal:

Developmental Dynamics

Year:

2004

Language:

english

File:

PDF, 1.51 MB

english, 2004

5

Identification of two putative novel folate receptor genes in humans and mouse

Ofer Spiegelstein, James D Eudy, Richard H Finnell

Journal:

Year:

2000

Language:

english

File:

PDF, 362 KB

english, 2000

6

Enantioselective synthesis and teratogenicity of propylisopropyl acetamide, a CNS-active chiral amide analogue of valproic acid

Ofer Spiegelstein, Meir Bialer, Matthias Radatz, Heinz Nau, Boris Yagen

Journal:

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

7

Arsenic-Induced Congenital Malformations in Genetically Susceptible Folate Binding Protein-2 Knockout Mice

Bogdan Wlodarczyk, Ofer Spiegelstein, Janée Gelineau-van Waes, Roseann L. Vorce, Xiufen Lu, Chris X. Le, Richard H. Finnell

Journal:

Toxicology and Applied Pharmacology

Year:

2001

Language:

english

File:

PDF, 137 KB

english, 2001

8

A Thorough QT/QTc Study With Laquinimod, a Novel Immunomodulator in Development for Multiple Sclerosis and Huntington Disease

Spiegelstein, Ofer, Mimrod, Dorit, Rabinovich, Laura, Eyal, Eli, Sprenger, Craig, Elgart, Anna, Samara, Emil, Morganroth, Joel

Journal:

Clinical Pharmacology in Drug Development

Year:

2018

Language:

english

File:

PDF, 282 KB

english, 2018

9

Stereoselective Pharmacokinetic Analysis of Valnoctamide, a CNS-Active Chiral Amide Analogue of Valproic Acid, in Dogs, Rats, and Mice

Spiegelstein, Ofer, Yagen, Boris, Bennett, Gregory D., Finnell, Richard H., Blotnik, Simcha, Bialer, Meir

Journal:

Therapeutic Drug Monitoring

Year:

2000

Language:

english

File:

PDF, 223 KB

english, 2000

10

Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate

Wlodarczyk, Bogdan, Spiegelstein, Ofer, Hill, Denise, Le, X. Chris, Finnell, Richard H.

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 267 KB

english, 2012

11

The Effect of CYP3A Induction and Inhibition on the Pharmacokinetics of Laquinimod, a Novel Neuroimmunomodulator

Elgart, Anna, Greenblatt, David J., Loupe, Pippa S., Zur, Arik A., Weiss, Sivan, Mimrod, Dorit, Spiegelstein, Ofer

Journal:

Clinical Pharmacology in Drug Development

Year:

2020

File:

PDF, 690 KB

2020

12

Teratogenicity of valproate conjugates with anticonvulsant activity in mice

Ofer Spiegelstein, Nithiananda Chatterjie, George Alexander, Richard H Finnell

Journal:

Epilepsy Research

Year:

2003

Language:

english

File:

PDF, 100 KB

english, 2003

13

Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents

Nina Isoherranen, Boris Yagen, José H Woodhead, Ofer Spiegelstein, Simcha Blotnik, Karen S Wilcox, Richard H Finnell, Gregory D Bennett, H Steve White, Meir Bialer

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 219 KB

english, 2003

14

Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice

Ofer Spiegelstein, Xiufen Lu, X.Chris Le, Aron Troen, Jacob Selhub, Stepan Melnyk, S.Jill James, Richard H. Finnell

Journal:

Toxicology Letters

Year:

2003

Language:

english

File:

PDF, 99 KB

english, 2003

15

Safety and in vivo immune assessment of escalating doses of oral laquinimod in patients with RRMS

Ziemssen, Tjalf, Tumani, Hayrettin, Sehr, Tony, Thomas, Katja, Paul, Friedemann, Richter, Nils, Samara, Emil, Spiegelstein, Ofer, Sorani, Ella, Bar-Ilan, Oren, Mimrod, Dorit, Hayardeny, Liat

Journal:

Journal of Neuroinflammation

Year:

2017

Language:

english

File:

PDF, 1012 KB

english, 2017

16

Erratum to: Folate-Regulated Changes in Gene Expression in the Anterior Neural Tube of Folate Binding Protein-1 (Folbp1)-Deficient Murine Embryos

Spiegelstein, Ofer, Cabrera, Robert M., Bozinov, Daniel, Wlodarczyk, Bogdan, Finnell, Richard H.

Journal:

Neurochemical Research

Year:

2014

Language:

english

File:

PDF, 130 KB

english, 2014

17

Folate-Regulated Changes in Gene Expression in the Anterior Neural Tube of Folate Binding Protein-1 (Folbp1)-Deficient Murine Embryos

Ofer Spiegelstein, Robert M. Cabrera, Daniel Bozinov, Bogdan Wlodarczyk, Richard H. Finnell

Journal:

Neurochemical Research

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

18

DNA Methylation in Folbp1 Knockout Mice Supplemented with Folic Acid during Gestation

Finnell, Richard H., Spiegelstein, Ofer, Wlodarczyk, Bogdan, Triplett, Aleata, Pogribny, Igor P., Melnyk, Stepan, James, Jill S.

Journal:

Journal of Nutrition

Year:

2002

Language:

english

File:

PDF, 85 KB

english, 2002

19

Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies

Ofer Spiegelstein, Amy Gould, Bogdan Wlodarczyk, Marlene Tsie, Xiufen Lu, Chris Le, Aron Troen, Jacob Selhub, Jorge A. Piedrahita, J. Michael Salbaum, Claudia Kappen, Stepan Melnyk, Jill James, Richar

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 198 KB

english, 2005

20

Absolute configuration of the four stereoisomers of valnoctamide (2-ethyl-3-methyl valeramide), a potentially new stereospecific antiepileptic and CNS drug

Michael Roeder, Ofer Spiegelstein, Volker Schurig, Meir Bialer, Boris Yagen

Journal:

Tetrahedron: Asymmetry

Year:

1999

Language:

english

File:

PDF, 290 KB

english, 1999

21

Stereoselective Pharmacokinetics and Pharmacodynamics of Propylisopropyl Acetamide, a CNS-Active Chiral Amide Analog of Valproic Acid

Ofer Spiegelstein, Boris Yagen, René H. Levy, Richard H. Finnell, Gregory D. Bennett, Michael Roeder, Volker Schurig, Meir Bialer

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.26 MB

1999

22

A phase 1 study to assess the pharmacokinetics, safety, and tolerability of fremanezumab doses (225 mg, 675 mg and 900 mg) in Japanese and Caucasian healthy subjects

Cohen-Barak, Orit, Weiss, Sivan, Rasamoelisolo, Michele, Faulhaber, Nicola, Yeung, Paul P, Loupe, Pippa S, Yoon, Esther, Gandhi, Mohit D, Spiegelstein, Ofer, Aycardi, Ernesto

Journal:

Year:

2018

Language:

english

File:

PDF, 591 KB

english, 2018

23

Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice

Nina Isoherranen, Boris Yagen, Ofer Spiegelstein, Richard H Finnell, Michelle Merriweather, Jose H Woodhead, Bogdan Wlodarczyk, H Steve White, Meir Bialer

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

24

Assessment Of the Pharmacokinetics, Pharmacodynamics And Safety Of Single Doses Of TV-1106, a Long-Acting Growth Hormone, in Healthy Japanese And Caucasian Subjects

Cohen-Barak, Orit, Barkay, Hadas, Rasamoelisolo, Michele, Butler, Kathleen, Yamada, Kazumasa, Bassan, Merav, Yoon, Esther, Spiegelstein, Ofer

Journal:

Clinical Pharmacology in Drug Development

Year:

2016

Language:

english

File:

PDF, 1.86 MB

english, 2016

25

Developmental Outcome of Levetiracetam, Its Major Metabolite in Humans, 2-Pyrrolidinone N-Butyric Acid, and Its Enantiomer (R)-α-ethyl-oxo-pyrrolidine Acetamide in a Mouse Model of Teratogenicity

Nina Isoherranen, Ofer Spiegelstein, Meir Bialer, Jing Zhang, Michelle Merriweather, Boris Yagen, Michael Roeder, Aleata A. Triplett, Volker Schurig, Richard H. Finnell

Journal:

Year:

2003

Language:

english

File:

PDF, 210 KB

english, 2003

26

Structure-Pharmacokinetic-Pharmacodynamic Relationships of yV-Alkyl Derivatives of the New Antiepileptic Drug Valproyl Glycinamide

Ofer Spiegelstein, Boris Yagen, Meir Bialer

Journal:

Year:

1999

Language:

english

File:

PDF, 734 KB

english, 1999

27

The effect of laquinimod, a novel immuno-modulator in development to treat Huntington disease, on the pharmacokinetics of ethinylestradiol and levonorgestrel in healthy young women

Elgart, Anna, Zur, Arik A., Mimrod, Dorit, Dror, Vered, Bar-Ilan, Oren, Korver, Tjeerd, Spiegelstein, Ofer

Journal:

European Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 809 KB

english, 2018

28

Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice

Ofer Spiegelstein, Xiufen Lu, X. Chris Le, Aron Troen, Jacob Selhub, Stepan Melnyk, S. Jill James, Richard H. Finnell

Journal:

Environmental Toxicology and Pharmacology

Year:

2005

Language:

english

File:

PDF, 153 KB

english, 2005

29

A population pharmacokinetic meta-analysis of custirsen, an antisense oligonucleotide, in oncology patients and healthy subjects

Edwards, Alena Y., Elgart, Anna, Farrell, Colm, Barnett-Griness, Ofra, Rabinovich-Guilatt, Laura, Spiegelstein, Ofer

Journal:

British Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 865 KB

english, 2017

30

Effect of Food on the Pharmacokinetics of Single- and Multiple-Dose Hydrocodone Extended Release in Healthy Subjects

Bond, Mary, Rabinovich-Guilatt, Laura, Selim, Sally, Darwish, Mona, Tracewell, William, Robertson, Philmore, Yang, Ronghua, Malamut, Richard, Colucci, Philippe, Ducharme, Murray P., Spiegelstein, Ofer

Journal:

Clinical Drug Investigation

Year:

2017

Language:

english

File:

PDF, 577 KB

english, 2017

31

Structure Activity Relationship of Human Microsomal Epoxide Hydrolase Inhibition by Amide and Acid Analogues of Valproic Acid

Ofer Spiegelstein, Deanna L. Kroetz, René H. Levy, Boris Yagen, Sussan I. Hurst, Micha Levi, Abdulla Haj-Yehia, Meir Bialer

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 52 KB

english, 2000

32

Su1084 Pharmacokinetics of Laquinimod in Patients With Active Moderate to Severe Crohn's Disease

D'Haens, Geert R., Sandborn, William, Colombel, Jean-Frederic, Mimrod, Dorit, Spiegelstein, Ofer, Brown, Kurt, Feagan, Brian G.

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 396 KB

english, 2014

33

Gas chromatographic determination of novel valproyl taurinamide derivatives in mouse and dog plasma

Nina Isoherranen, Boris Yagen, Ofer Spiegelstein, Amir Steinman, Richard H Finnell, Meir Bialer

Journal:

Journal of Chromatography B

Year:

2003

Language:

english

File:

PDF, 647 KB

english, 2003

34

Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice

Ofer Spiegelstein, Michelle Y. Merriweather, Ned J. Wicker, Richard H. Finnell

Journal:

Birth Defects Research Part A: Clinical and Molecular Teratology

Year:

2003

Language:

english

File:

PDF, 87 KB

english, 2003

35

Impact of dosing regimen of custirsen, an antisense oligonucleotide, on safety, tolerability and cardiac repolarization in healthy subjects

Rabinovich-Guilatt, Laura, Elgart, Anna, Erisson, Lavi, Willsie, Sandra K., Tessler, Shoshi, Barnett-Griness, Ofra, Pande, Amitkumar, Spiegelstein, Ofer

Journal:

British Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 853 KB

english, 2015

36

Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington Disease

Rabinovich-Guilatt, Laura, Steiner, Lilach, Hallak, Hussein, Pastino, Gina, Muglia, Pierandrea, Spiegelstein, Ofer

Journal:

British Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 554 KB

english, 2017

37

Isolation of N,N-dialkylated derivatives of valproylglycinamide from dog plasma by active charcoal adsorption and their quantification by high-performance liquid chromatography

Ofer Spiegelstein, Meir Bialer, Boris Yagen

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1997

Language:

english

File:

PDF, 336 KB

english, 1997

38

Pathobiology and Genetics of Neural Tube Defects

Richard H. Finnell, Amy Gould, Ofer Spiegelstein

Journal:

Year:

2003

Language:

english

File:

PDF, 107 KB

english, 2003

39

A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects

Adar, Liat, Avisar, Noa, Lammerich, Andreas, Kleiman, Robert B., Spiegelstein, Ofer

Journal:

Drug Design Development and Therapy

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

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